Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[HIV encephalopathy].

Yoshiharu Miura1, Yoshio Koyanagi

  • 1Laboratory of Viral Pathogenesis, AIDS Research Center, Institute for Virus Research, Kyoto University.

Rinsho Shinkeigaku = Clinical Neurology
|February 2, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[HIV-Associated Neurocognitive Disorders (HAND)].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same author

[Progressive Multifocal Leukoencephalopathy].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same author

Seven-year Follow-up of Cerebellar Type 1 Metabotropic Glutamate Receptor Availability in a Family With Spinocerebellar Ataxia Type 19/21.

Clinical nuclear medicine·2026
Same author

Characterizing spinal cord atrophy in multiple sclerosis patients without disease activity or brain atrophy progression.

Multiple sclerosis and related disorders·2026
Same author

Natalizumab-Associated Progressive Multifocal Leukoencephalopathy After Natalizumab Extended Interval Dosing Therapy in Japan.

Neurology(R) neuroimmunology & neuroinflammation·2025
Same author

[An autopsy case of non-drug related progressive multifocal leukoencephalopathy in a background of rheumatoid arthritis].

Rinsho shinkeigaku = Clinical neurology·2025

Researchers identified TNF-related apoptosis-inducing ligand as a neurotoxic factor in HIV encephalopathy. They also found CD14 and CD63 genes that inhibit HIV-1-induced brain cell damage, offering new therapeutic targets.

Area of Science:

  • Neurovirology
  • Immunology
  • Molecular Biology

Context:

  • HIV encephalopathy is a complex viral disease affecting the brain, with damage extending to neurons despite HIV infection being restricted to macrophages and microglia.
  • The precise mechanisms underlying HIV encephalopathy remain incompletely understood, necessitating further investigation into viral and host factors.

Purpose:

  • To elucidate the mechanisms of HIV encephalopathy by developing a human cell-transplanted mouse model.
  • To identify neurotoxic host factors and protective host factors involved in HIV-1-induced brain damage.

Summary:

  • A novel HIV-1-infected human cell-transplanted mouse model was established, leading to the identification of TNF-related apoptosis-inducing ligand as a neurotoxic host factor.
  • Co-culture systems revealed preferential damage to neurons and neural stem cells by HIV-1-infected macrophages.

Related Experiment Videos

  • Two anti-HIV genes, CD14 and CD63, were identified as inhibitors of HIV-1-induced cytotoxicity, suggesting they may limit CXCR4-using HIV-1 expansion in the brain.

    • Impact:

    • This research contributes to understanding HIV encephalopathy pathogenesis.
    • Findings pave the way for developing novel therapeutic strategies for HIV encephalopathy and other central nervous system diseases.