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Hepatic lipase C-514T polymorphism and its association with high-density lipoprotein cholesterol level in Tehran
Maryam S Daneshpour1, Mehdi Hedayati, Fereidoun Azizi
1Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Background:
The study was conducted to obtain the frequency of the hepatic lipase C-514T polymorphism and evaluate its relation with serum HDL cholesterol levels in Tehran.
Methods:
A segment of the gene mentioned was amplified by polymerase chain reaction in 545 people and the restriction fragment length polymorphism revealed.
Results:
The T allele frequency was 0.154. No significant relationship between HDL cholesterol levels and C-514T polymorphism was found even after adjusting for age, body mass index and blood pressure.
Conclusion:
The frequency of the polymorphism is similar to other Caucasian populations and no significant relationship exists between the non-CC genotype of the gene and a higher serum HDL cholesterol concentration.
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