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Related Experiment Videos

[Nephrolithiasis and topiramate].

H Alarcón-Martínez1, C Casas-Fernández, N Escudero-Rodríguez

  • 1Servicio de Neuropediatría, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. helenaalarconmartinez@yahoo.com

Revista De Neurologia
|February 2, 2006
PubMed
Summary
This summary is machine-generated.

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Topiramate (TPM) can effectively treat childhood epilepsy but may cause kidney stones. Doctors should assess risk factors before prescribing TPM, especially for children with certain neurological conditions.

Area of Science:

  • Pediatric Neurology
  • Pharmacology

Background:

  • Topiramate (TPM) is a widely used antiepileptic drug in pediatric epilepsy due to its broad efficacy.
  • TPM's carbonic anhydrase inhibition, while crucial for its antiepileptic action, is linked to side effects like nephrolithiasis.

Observation:

  • This report details two cases of medication-resistant infantile epilepsy (Dravet syndrome and Lennox-Gastaut syndrome) treated with TPM add-on therapy.
  • Both patients achieved significant seizure control but subsequently developed TPM-induced nephrolithiasis.
  • One case involved concurrent adrenocorticotropic hormone (ACTH) treatment, a potential contributing factor, while the other had no identified risk factors.

Findings:

  • The exact incidence of TPM-induced nephrolithiasis in children remains unknown, with limited prior reports.

Related Experiment Videos

  • The cases highlight that nephrolithiasis can occur even without apparent predisposing factors.
  • TPM-induced nephrolithiasis often necessitates discontinuation of the medication.

    • Implications:

    • Pre-prescription assessment of nephrolithiasis risk factors is crucial for pediatric patients.
    • Implementing preventive strategies, particularly for children with encephalopathies or reduced mobility, is recommended.
    • Understanding the physiopathogenic mechanisms and risk factors can guide management of this adverse event.