Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tramadol sustained-release capsules.

Gillian M Keating1

  • 1Adis International Limited, Auckland, New Zealand.

Drugs
|February 3, 2006
PubMed
Summary
This summary is machine-generated.

New tramadol sustained-release (SR) capsules offer smoother plasma profiles and improved tolerability for chronic pain management. This formulation provides effective pain relief with less nausea compared to immediate-release tramadol.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Afatinib in advanced NSCLC: a profile of its use.

Drugs & therapy perspectives : for rational drug selection and use·2019
Same author

Afatinib in advanced NSCLC: a profile of its use.

Drugs & therapy perspectives : for rational drug selection and use·2018
Same author

Ticagrelor: A Review in Long Term Secondary Prevention of Cardiovascular Events.

Drugs·2017
Same author

Eluxadoline: A Review in Diarrhoea-Predominant Irritable Bowel Syndrome.

Drugs·2017
Same author

Sorafenib: A Review in Hepatocellular Carcinoma.

Targeted oncology·2017
Same author

Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex<sup>®</sup>): A Review in Multiple Sclerosis-Related Spasticity.

Drugs·2017
Same journal

Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

Drugs·2026
Same journal

Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

Drugs·2026
Same journal

Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

Drugs·2026
Same journal

Relacorilant: First Approval.

Drugs·2026
Same journal

Developmental Progress and Future Potential for Inhaled Biologics in the Treatment of Respiratory Diseases.

Drugs·2026
Same journal

Linerixibat: First Approval.

Drugs·2026
See all related articles

Area of Science:

  • Pharmacology
  • Pain Management
  • Drug Formulation

Background:

  • Tramadol is a synthetic analgesic used for pain relief.
  • Sustained-release (SR) formulations aim to improve dosing convenience and patient compliance.
  • Optimizing tramadol delivery is crucial for managing chronic pain effectively.

Purpose of the Study:

  • To evaluate the pharmacokinetic profile and clinical efficacy of tramadol SR capsules.
  • To compare tramadol SR capsules with immediate-release (IR) tramadol and SR tablets.
  • To assess the tolerability and patient outcomes with tramadol SR capsules in chronic pain.

Main Methods:

  • Pharmacokinetic studies comparing SR capsules to SR tablets and IR capsules.
  • Clinical trials assessing efficacy and tolerability in patients with moderate to severe chronic low back pain.

Related Experiment Videos

  • Postmarketing observational study evaluating tramadol SR capsules (50-200 mg twice daily) in a large patient cohort.

    • Main Results:

    • Tramadol SR capsules demonstrated smoother plasma concentration profiles, reduced peak concentrations, and less variability compared to SR tablets.
    • SR capsules showed equivalent bioavailability to IR capsules but with reduced fluctuations.
    • Equivalent efficacy to tramadol IR was observed for SR capsules in chronic low back pain, with significantly lower incidence of nausea.
    • Initiating treatment with lower doses of SR capsules and escalating improved tolerability.
    • A postmarketing study showed significant improvements in pain intensity and frequency with tramadol SR capsules.

    Conclusions:

    • Tramadol SR capsules offer an improved pharmacokinetic profile and enhanced tolerability for managing moderate to severe chronic pain.
    • The twice-daily dosing of tramadol SR capsules provides effective pain relief with a better side-effect profile compared to immediate-release formulations.
    • Tramadol SR capsules represent a valuable therapeutic option for patients with chronic pain requiring sustained analgesia.