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Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
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Strategies for evaluating B*18 allelic diversity by sequence-based typing applied to studies of a population from
Tissue Antigens
|February 3, 2006
Abstract:
Strategies to resolve B*18 alleles which carry a deletion in intron 1 close to the 5' end of exon 2 relative to other HLA-B alleles or a null allele mutation in exon 1 and to resolve ambiguities among allele combinations including B*18 are described. B*18 allele frequencies from volunteer donors recruited for two hematopoietic stem cell registries show the presence of two alleles, B*180101 and B*1802, in a population from Singapore and only B*180101 in African-Americans.
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