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The association between HLA class II haplotype with Graves' disease in Thai population

T Wongsurawat1, J Nakkuntod, P Charoenwongse

  • 1Inter-Department of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand.

Tissue Antigens
|February 3, 2006
PubMed

Insights

The study identified specific human leukocyte antigen (HLA) alleles and haplotypes associated with Graves

Area of Science:

  • Immunogenetics
  • Human Leukocyte Antigen (HLA) complex
  • Autoimmune diseases

Background:

  • Graves' disease (GD) is an autoimmune disorder affecting the thyroid.
  • Genetic factors, particularly HLA alleles, are implicated in GD susceptibility.
  • Previous studies have shown ethnic variations in HLA associations with GD.

Purpose of the Study:

  • To investigate the association of HLA-DRB1, -DQA1, and -DQB1 alleles and haplotypes with Graves' disease in the Thai population.
  • To identify specific genetic markers for GD susceptibility in Asians.

Main Methods:

  • Analysis of HLA-DRB1, -DQA1, and -DQB1 allele and haplotype distribution.
  • Comparison between 124 Graves' disease patients and 124 healthy controls from the Thai population.
  • Statistical analysis including odds ratios (OR) and p-values.

Main Results:

  • The DRB1*1602-DQA1*0102-DQB1*0502 haplotype was significantly increased in GD patients (OR = 2.55, P = 0.0209).
  • The DRB1*07-DQA1*0201-DQB1*0201 (OR = 0.32, P = 0.039) and HLA-DRB1*12-DQA1*0601-DQB1*0301 (OR = 0.28, P = 0.0025) haplotypes were significantly decreased in GD patients.
  • A protective DRB1*07 allele in Thais shares a characteristic with a Caucasian protective allele.

Conclusions:

  • The DRB1*1602 allele and its linked haplotype (DRB1*1602-DQA1*0102-DQB1*0502) may serve as a genetic susceptibility marker for Graves' disease in the Asian population.
  • Findings highlight ethnic differences in HLA associations with GD.
  • Further research into specific amino acid residues may elucidate GD pathogenesis.

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