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Haemagglutination by parvovirus B19

K E Brown1, B J Cohen

  • 1Virus Reference Laboratory, Central Public Health Laboratory, London, U.K.

The Journal of General Virology
|August 1, 1992
PubMed

Insights

Human parvovirus B19 can agglutinate primate red blood cells, a function previously unobserved. An IgM-like inhibitor in plasma masks this activity, suggesting a specific receptor on target cells.

Area of Science:

  • Virology
  • Hematology

Background:

  • Human parvovirus B19 belongs to the autonomous parvoviridae family.
  • Unlike other genus members, B19 has not been known to agglutinate red blood cells.

Purpose of the Study:

  • To investigate the red blood cell agglutination properties of human parvovirus B19.
  • To identify potential mechanisms masking B19's agglutination activity.

Main Methods:

  • Testing red blood cell agglutination with human parvovirus B19.
  • Investigating the effect of plasma-derived inhibitors on agglutination.

Main Results:

  • Human parvovirus B19 agglutinates primate red blood cells.
  • An IgM-like inhibitor present in plasma masks this agglutination activity.
  • This suggests the presence of a specific receptor for B19 on erythroid precursor cells.

Conclusions:

  • Human parvovirus B19 possesses red blood cell agglutination capabilities.
  • Plasma inhibitors can mask B19's interaction with red blood cells.
  • A specific receptor on erythroid precursors likely mediates B19 binding.

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