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Updated: Aug 13, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Methods to test for association between a disease and a multi-allelic marker applied to a candidate region
Rachid El Galta1, Li Hsu, Jeanine J Houwing-Duistermaat
1Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, P.O. Box 9604, 2300RC Leiden, The Netherlands. r.elgalta@lumc.nl
Abstract:
We report the analysis results of the Genetic Analysis Workshop 14 simulated microsatellite marker dataset, using replicate 50 from the Danacaa population. We applied several methods for association analysis of multi-allelic markers to case-control data to study the association between Kofendrerd Personality Disorder and multi-allelic markers in a candidate region previously identified by the linkage analysis. Evidence for association was found for marker D03S0127 (p < 0.01). The analyses were done without any prior knowledge of the answers.
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