Strontium ranelate: a physiological approach for an improved bone quality.

Area of Science:

• Bone Biology and Pharmacology
• Osteoporosis Research
• Pharmacological Interventions for Bone Diseases

Background:

• In vitro studies suggest strontium ranelate promotes osteoblast replication and inhibits osteoclast activity.
• Strontium ranelate demonstrates a dual action, enhancing bone formation while decreasing resorption.

Purpose of the Study:

• To evaluate the in vivo effects of strontium ranelate on bone formation, resorption, and mechanical properties.
• To assess the efficacy of strontium ranelate in preventing bone loss and improving bone quality in animal models.

Main Methods:

• In vitro assessment of osteoblastic and osteoclastic activity.
• In vivo studies in growing animals and intact female rats, including ovariectomized models.
• Evaluation of bone mass, dimension, microarchitecture, and mechanical properties (maximal load, energy to failure).

Main Results:

• Strontium ranelate treatment led to bone gain, improved geometry, and enhanced microarchitecture in growing animals.
• In intact female rats, a 2-year exposure significantly improved vertebral and femoral mechanical properties, including bone mass, dimension, and quality.
• Treatment prevented ovariectomy-induced bone loss and preserved vertebral mechanical properties and trabecular microarchitecture.

Conclusions:

• Strontium ranelate treatment results in the formation of new bone with superior resistance to fracture.
• The drug effectively improves bone mechanical properties and microarchitecture, offering protection against bone loss and enhancing bone strength.