Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptic ulcer disease today.

Yuhong Yuan1, Ireneusz T Padol, Richard H Hunt

  • 1McMaster University, Health Science Centre, Hamilton, ON, Canada.

Nature Clinical Practice. Gastroenterology & Hepatology
|February 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brittleness mechanisms and toughening strategies of electrical insulating polymer materials under extreme cryogenic conditions.

RSC advances·2026
Same author

From the 10-20 mm gray zone to a 15 mm stone size cutoff for pediatric urolithiasis management: do guidelines need revisiting? . A systematic review and meta-analysis by the EAU Section of Endourology.

Minerva urology and nephrology·2026
Same author

The impact of global recruitment and country income on placebo rates in inflammatory bowel disease clinical trials.

Journal of Crohn's & colitis·2026
Same author

Recurrence rates following endoscopic mucosal resection versus endoscopic submucosal dissection for colorectal polyps: a systematic review and meta-analysis of randomized controlled trials.

Surgical endoscopy·2026
Same author

Biologics and small molecules for perianal Crohn's disease: a systematic review and meta-analyses of randomized placebo-controlled trials.

Inflammatory bowel diseases·2026
Same author

Patient-Reported Outcomes in Clinical Trials of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same journal

Proteomic and metabolic prediction of response to therapy in gastrointestinal cancers.

Nature clinical practice. Gastroenterology & hepatology·2009
Same journal

A perfect storm.

Nature clinical practice. Gastroenterology & hepatology·2009
Same journal

Gastric electric stimulation is a viable option in gastroparesis treatment.

Nature clinical practice. Gastroenterology & hepatology·2009
Same journal

Misconception of treatment for liver disease unique to pregnancy.

Nature clinical practice. Gastroenterology & hepatology·2009
Same journal

Probiotic prophylaxis in acute pancreatitis: prudence required.

Nature clinical practice. Gastroenterology & hepatology·2009
Same journal

Duration of treatment with albendazole for hepatic toxocariasis.

Nature clinical practice. Gastroenterology & hepatology·2009
See all related articles

While peptic ulcer disease has declined, ulcer bleeding, particularly in the elderly, is rising. Key challenges include managing H. pylori eradication failures and preventing NSAID-associated ulcers.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Peptic ulcer disease incidence has decreased due to H2 blockers, PPIs, coxibs, and H. pylori eradication.
  • Despite this, ulcer bleeding, especially in elderly patients, has increased.
  • Current management faces challenges in H. pylori eradication, NSAID/aspirin-induced ulcer prevention, and treating non-NSAID/non-H. pylori ulcers.

Purpose of the Study:

  • To review current management issues in peptic ulcer disease.
  • To discuss diagnostic considerations and therapeutic approaches for H. pylori, NSAID/aspirin use, and acid hypersecretory states.
  • To highlight challenges in treating non-NSAID, non-H. pylori-associated peptic ulcers.

Main Methods:

  • Review of current literature and clinical practice guidelines.
  • Analysis of diagnostic considerations including H. pylori status, NSAID/aspirin use, and acid hypersecretory states.

Related Experiment Videos

  • Discussion of therapeutic strategies for H. pylori eradication and NSAID/aspirin users.

    • Main Results:

    • Combined antisecretory and antibiotic therapy is first-line for H. pylori eradication.
    • Risk assessment is crucial for selecting anti-inflammatory drugs (NSAIDs vs. coxibs) in high-risk patients, especially those on aspirin.
    • Testing and eradicating H. pylori before NSAID therapy or in current users with ulcer history is recommended.

    Conclusions:

    • Managing H. pylori eradication failures and preventing NSAID/aspirin-induced ulcers remain significant clinical challenges.
    • Careful patient risk assessment guides the choice of anti-inflammatory agents.
    • Further understanding of pathophysiology is needed for non-NSAID, non-H. pylori peptic ulcers.