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Updated: Aug 11, 2026
Establishment of Deep Hypothermic Circulatory Arrest in Rats
Published on: December 16, 2022
Clinical predictors for prolonged intensive care unit stay in adults undergoing thoracic aortic surgery requiring
John G Augoustides1, Alberto Pochettino, E Andrew Ochroch
1Department of Anesthesia, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA. yiandoc@hotmail.com
Objective:
The purpose of this study was to describe clinical predictors for prolonged length of stay in the intensive care unit (PLOS-ICU) after adult thoracic aortic surgery requiring standardized deep hypothermic circulatory arrest (DHCA); and to determine the incidence of PLOS-ICU after DHCA, univariate predictors for PLOS-ICU, and multivariate predictors for PLOS-ICU.
Study Design:
A retrospective and observational study. PLOS-ICU was defined as longer than 5 days in the ICU.
Study Setting:
Cardiothoracic operating rooms and the ICU.
Participants:
All adults requiring thoracic aortic repair with DHCA INTERVENTIONS: None.
Main Results:
The cohort size was 144. The incidence of PLOS-ICU was 27.8%. The mortality rate was 11.1%. Univariate predictors for PLOS-ICU were age, stroke, DHCA duration, vasopressor dependence >72 hours, mediastinal re-exploration for bleeding, and renal dysfunction. Multivariate predictors for PLOS-ICU were stroke, vasopressor dependence >72 hours, and renal dysfunction.
Conclusions:
PLOS-ICU after DHCA is common. The identified multivariate predictors merit further hypothesis-driven research to enhance perioperative protection of the brain, kidney, and cardiovascular system.
