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Updated: Aug 11, 2026

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
Published on: November 8, 2018
Folinic acid-responsive seizures initially responsive to pyridoxine
Joost Nicolai1, Vivianne H J M van Kranen-Mastenbroek, Ron A Wevers
1Department of Neurology University Hospital Maastricht, Maastricht, The Netherlands. jnic@sneu.azm.nl
Abstract:
This report presents a male who developed clonic seizures on the day he was born. The next day, the diagnosis of pyridoxine-dependent seizures was made. However, contradictory to this diagnosis, seizures reappeared despite treatment with pyridoxine. Seizures ceased after folinic acid was initiated. The clinical and biochemical characteristics of folinic acid-responsive seizures are reviewed. Treatment with folinic acid should be considered in neonatal seizures of unknown origin that do not respond to pyridoxine, or manifest a transient response to pyridoxine.
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