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Related Experiment Videos

Cybil induced hepatobiochemical changes in wistar rats.

Vijay Kr Singh1, Poonam Dixit, Prabhu N Saxena

  • 1Toxicology lab, Department of Zoology, School of Life Sciences, Dr. B.R.Amedkar University, Agra-282 002, India.

Journal of Environmental Biology
|February 8, 2006
PubMed
Summary

Cypermethrin (Cybil) exposure caused significant biochemical changes in rat livers, affecting key metabolic indicators. These alterations suggest potential liver impairment following acute and subacute Cypermethrin exposure.

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Area of Science:

  • Toxicology
  • Biochemistry
  • Environmental Health

Background:

  • Cypermethrin is a widely used synthetic pyrethroid insecticide.
  • Pesticide exposure can lead to various adverse health effects, particularly impacting organs like the liver.
  • Understanding the specific biochemical alterations induced by Cypermethrin is crucial for risk assessment.

Purpose of the Study:

  • To investigate the biochemical changes in the liver of Wistar rats following acute and subacute oral exposure to Cypermethrin (25% EC formulation, Cybil).
  • To determine the LD50 value of Cybil in Wistar rats.
  • To correlate observed biochemical alterations with potential liver impairment.

Main Methods:

  • Oral intubation of Wistar rats with Cybil at acute (80mg/kg for 1 day) and subacute (4mg/kg for 7, 14, 21 days) doses.

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  • Biochemical analysis of liver tissue, including glycogen, cholesterol, total lipid levels, and acid and alkaline phosphatase activities.
  • Comparison of results with simultaneously run control groups.

    • Main Results:

    • The LD50 of Cybil was determined to be 622mg/kg body weight.
    • Both acute and subacute doses of Cybil significantly increased liver glycogen, cholesterol, and total lipid levels.
    • Acid phosphatase activity was enhanced, while alkaline phosphatase activity was decreased in the exposed groups compared to controls.
    • These biochemical changes indicate an impairment of normal liver physiology.

    Conclusions:

    • Cypermethrin (Cybil) exposure induces significant dose-dependent biochemical alterations in the rat liver.
    • The observed changes in key metabolic indicators suggest a disruption of liver function.
    • Further research is warranted to fully elucidate the long-term toxicological implications of Cypermethrin exposure.