Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioinert solution-cross-linked hydrogen-bonded multilayers on colloidal particles.

Sung Yun Yang1, Daeyeon Lee, Robert E Cohen

  • 1Department of Materials Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|February 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Solvent-triggered reconfiguration of optical physical unclonable functions.

Nature communications·2026
Same author

Extreme Nanoconfinement Dramatically Enhances Small Molecule Solubility in Nonpolar Polymers.

ACS nano·2026
Same author

Diazo-6Bx, a Six-Branched Diazo Cross-Linker, Enables High-Fidelity Patterning for Solution-Processed Electronics with Stable Operation.

ACS nano·2026
Same author

Proton pump inhibitors are associated with reduced periodontal disease severity.

JADA foundational science·2026
Same author

Squeezing new information out of small systems.

The Journal of chemical physics·2026
Same author

pH-Tunable, Ligand-Free Selective Separation of Rare Earth Elements Using Silica Nanoparticles.

ACS applied materials & interfaces·2026

Bioinert polyelectrolyte multilayers were created using hydrogen-bonding interactions and cross-linked for stability. These coatings resist cell adhesion, showing promise for biomedical applications.

Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Surface Chemistry

Background:

  • Developing stable, bioinert coatings is crucial for biomedical applications.
  • Layer-by-layer assembly is a versatile technique for creating thin films.
  • Hydrogen-bonding interactions offer a non-covalent method for film formation.

Purpose of the Study:

  • To develop and characterize bioinert polyelectrolyte multilayers on colloidal particles.
  • To investigate the stability and cell resistance of these multilayer films.
  • To explore a novel cross-linking method for enhancing film durability.

Main Methods:

  • Layer-by-layer assembly of poly(acrylic acid) and polyacrylamide at low pH.
  • Utilizing hydrogen-bonding interactions for film deposition on colloidal particles.

Related Experiment Videos

  • Cross-linking the multilayer films using a carbodiimide aqueous solution.

    • Main Results:

    • Uniform multilayer coatings were achieved on colloidal particles without flocculation.
    • Cross-linked films demonstrated excellent stability in physiological conditions (pH 7.4, PBS).
    • Untreated films dissolved, while cross-linked films resisted dissolution.
    • Both flat and colloidal surfaces with multilayer coatings showed resistance to mammalian cell adhesion.

    Conclusions:

    • A novel, solution-based cross-linking method effectively stabilizes bioinert H-bonded polyelectrolyte multilayers.
    • These stable, bioinert coatings exhibit excellent resistance to mammalian cell adhesion.
    • The developed coatings hold significant potential for various biomedical applications.