Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epigenetics and airways disease.

Ian M Adcock1, Paul Ford, Kazuhiro Ito

  • 1Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK. ian.adcock@imperial.ac.uk

Respiratory Research
|February 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Desmoglein-2 dysregulation impairs epithelial barrier integrity in eosinophilic asthma.

Respiratory research·2026
Same author

MiR-146a-armed exosomes reverse immunosuppressive networks in NSCLC by dual-targeting of MYD88/STAT3 and PD-L1 axes.

International immunopharmacology·2026
Same author

CD207-Positive Dendritic Cells Promote Emphysema Through CD8<sup>+</sup> T Cell Pathway in Chronic Obstructive Pulmonary Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Nasal gene expression shows a distinct signature in type 2-high asthma but not in type 2-low disease.

The Journal of allergy and clinical immunology·2026
Same author

Type 2 Biomarkers as Mediators of Clinical Remission With Biologics in Severe Asthma.

Allergy·2025
Same author

Proteomic and Transcriptomic Signatures of Poor Asthma Symptom Control in the U-BIOPRED Cohort.

Allergy·2025
Same journal

Real-time algorithm-driven ventilation feedback to improve lung-protective ventilation in patients with ARDS (REALVENT-study): study protocol for a multicentre randomised controlled trial.

Respiratory research·2026
Same journal

Identification and functional validation of lactylation-related hub genes in idiopathic pulmonary fibrosis based on multi-omics analysis.

Respiratory research·2026
Same journal

NSUN2-mediated m5C modification of E2F1 promotes lung adenocarcinoma progression via the RAD54L signaling axis.

Respiratory research·2026
Same journal

Direct visualisation and measurement of lung microstructure reveal insights into extracellular matrix dysregulation in COPD.

Respiratory research·2026
Same journal

Proteo-metabolomic insights into the progression of chronic obstructive pulmonary disease and lung function decline.

Respiratory research·2026
Same journal

Lung ultrasound feature tracking to quantify regional lung strain in mechanically ventilated pigs.

Respiratory research·2026
See all related articles

Epigenetics involves heritable gene expression changes without altering DNA sequence. These crucial epigenetic modifications are linked to diseases and offer potential for new therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Epigenetics describes heritable gene expression changes via DNA and histone post-translational modifications.
  • These modifications (acetylation, methylation, etc.) are vital for cell differentiation and maintaining expression profiles.
  • Historically, human disease research prioritized genetics over non-coding epigenetic events.

Purpose of the Study:

  • To highlight the significance of epigenetic regulation in development and disease.
  • To underscore the link between disrupted epigenetic processes and various pathologies.
  • To explore the potential of epigenetic modifications in disease diagnosis and therapy.

Main Methods:

  • Review of epigenetic mechanisms including histone acetylation, methylation, ubiquitination, sumoylation, and phosphorylation.

Related Experiment Videos

  • Analysis of the role of epigenetics in mammalian development and cell type diversity.
  • Examination of the connection between epigenetic dysregulation and human diseases like cancer and respiratory conditions.

    • Main Results:

    • Epigenetic regulation is essential for mammalian development and cellular stability.
    • Disruption of epigenetic processes is implicated in major diseases, including cancer and respiratory illnesses.
    • Enzymes regulating epigenetic modifications show abnormal expression in respiratory disease patients.

    Conclusions:

    • Epigenetic alterations are increasingly recognized as contributors to human pathologies.
    • Epigenetic modifications, while stable, are potentially reversible, opening avenues for epigenetic therapies.
    • Further research and diagnostic tools are needed to fully elucidate the role of epigenetics in disease.