Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulatory T cell-mediated transplantation tolerance.

Ankit Bharat1, Ryan Courtney Fields, T Mohanakumar

  • 1Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Immunologic Research
|February 8, 2006
PubMed
Summary

Naturally occurring regulatory T cells, particularly CD4(+)CD25(+) T cells, are crucial for immune tolerance. Understanding their function offers potential for treating autoimmune diseases and improving allotransplantation outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung Transplant for Refractory Lung-Limited Stage IV Non-Small Cell Lung Cancer.

JAMA·2026
Same author

B6 Donor Lungs Develop Chronic Lung Allograft Dysfunction-like Pathology Across Histocompatibility Mismatches in Murine Lung Transplantation.

Transplantation direct·2026
Same author

Hepatoid adenocarcinoma of the lung: clinicopathologic and molecular analysis of 17 cases.

Virchows Archiv : an international journal of pathology·2026
Same author

Performance of bilateral bronchoalveolar lavage during routine transplant surveillance bronchoscopy changes management.

JHLT open·2026
Same author

Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen.

bioRxiv : the preprint server for biology·2026
Same author

Non-Small Cell Lung Cancer, Version 4.2026, NCCN Clinical Practice Guidelines In Oncology.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • Naturally occurring regulatory T cells (Tregs) maintain self- and foreign-antigen tolerance.
  • CD4(+)CD25(+) T cells represent a potent subset of Tregs with significant tolerogenic capabilities.

Purpose of the Study:

  • To review the molecular mechanisms underlying the development and function of CD4(+)CD25(+) T cells.
  • To explore the role of these regulatory T cells in chronic lung allograft rejection.

Main Methods:

  • Literature review focusing on regulatory T cell biology.
  • Analysis of studies investigating CD4(+)CD25(+) T cell function in transplantation models.

Main Results:

  • CD4(+)CD25(+) T cells are key mediators of immune tolerance.

Related Experiment Videos

  • These cells play a critical role in preventing both autoimmune responses and graft rejection.

    • Conclusions:

    • Insights into CD4(+)CD25(+) T cell function can inform therapies for autoimmune disorders.
    • Targeting regulatory T cells may facilitate immunosuppression-free lung allotransplantation.