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Management of cranial base chondrosarcomas
John E Wanebo1, Ruth E Bristol, Randall R Porter
1Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA.
Neurosurgery
|February 8, 2006
Summary
Cranial base chondrosarcomas require a multidisciplinary team approach for optimal management. Surgical resection and adjuvant therapies offer improved long-term survival rates for these rare tumors.
Area of Science:
- Oncology
- Neurosurgery
- Radiology
Background:
- Chondrosarcomas are rare, infiltrative cranial base tumors.
- Their location complicates complete surgical resection due to proximity to vital structures.
Observation:
- A retrospective review of 23 cranial base chondrosarcoma patients treated between 1983-2003.
- Mean age at presentation was 43 years; 14 females and 9 males.
- Follow-up ranged from 8 months to 25 years.
Findings:
- 23 patients underwent 43 surgical resections; 10 received adjuvant radiation.
- Absolute 5-year survival rate is 93%; 10-year survival rate is 71%.
- 13 of 14 patients with 5 years of follow-up are living; 4 have no evidence of disease.
Implications:
- A team approach is crucial for managing complex cranial base chondrosarcomas.
- Maximal cytoreductive surgery is recommended initially to minimize neurological damage.
- Adjuvant stereotactic radiosurgery can effectively treat residual or recurrent disease.
