[Gardner syndrome: clinical and epidemiologic up to date]

Area of Science:

• Genetics
• Oncology
• Gastroenterology

Background:

• Gardner syndrome is characterized by familial colonic polyposis, osteomas, soft tissue cysts, and fibrous lesions.
• It involves early onset of osteomas and dental inclusions in maxillary bones.
• The condition is life-threatening due to poor quality of life and 100% progression of colonic polyps to colon cancer.

Purpose of the Study:

• To review the pathophysiology and clinical aspects of Gardner syndrome.
• To report institutional data on epidemiology and clinical presentation.
• To develop a clinical protocol for early detection.

Main Methods:

• Literature review of pathophysiologic and clinical aspects.
• Analysis of institutional clinical data on epidemiology and presentation.
• Elaboration of a clinical protocol for early detection.

Main Results:

• Gardner syndrome presents with a distinct set of symptoms including colonic polyposis and osteomas.
• High-risk progression to colon cancer necessitates proactive management.
• Institutional data provides insights into the condition's epidemiology and clinical manifestations.

Conclusions:

• Gardner syndrome is a severe condition requiring comprehensive understanding and management.
• Early detection and intervention are critical for improving patient outcomes.
• A standardized clinical protocol can aid in the early identification of Gardner syndrome.