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Updated: Aug 11, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica
S M Staroverov1, M A Kuznetsov, P N Nesterenko
1Chemical Department, Lomonosov State University, Leninskie Gory, 119992 Moscow, Russian Federation.
Abstract:
A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
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