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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
[Visual dysfunction and arterial occlusion: is there an association with factor V Leiden mutation? Four case reports]
1Unité de Neuro-ophtalmologie, Hôpital Ophtalmique Jules Gonin, Lausanne, Suisse.
Journal Francais D'Ophtalmologie
|February 9, 2006
Summary
Factor V Leiden mutation, a cause of procoagulant state, may increase risk for arterial clots. This study found the mutation in four patients with arterial occlusions and visual defects, suggesting a potential link to arterial thrombosis.
Area of Science:
- Genetics and Thrombosis
- Vascular Medicine
Background:
- The factor V Leiden mutation confers resistance to activated protein C, leading to a procoagulant state.
- Its role in arterial thrombosis, unlike venous thrombosis, is not well-established.
Observation:
- Four patients (3 female, 1 male, aged 32-58) presented with arterial occlusions causing visual field defects.
- All patients exhibited resistance to activated protein C and a heterozygous factor V Leiden mutation.
- Two stroke patients also had elevated antiphospholipid antibodies or a patent foramen ovale.
Findings:
- The study identified factor V Leiden mutation in all four patients with arterial occlusive events.
- Two patients had no other identifiable thrombophilic risk factors.
- This suggests factor V Leiden may be a predisposing factor for arterial occlusion.
Implications:
- The factor V Leiden mutation, even heterozygously, may contribute to arterial thrombotic events.
- Further research is warranted to clarify the precise role of factor V Leiden in arterial disease.
- Highlights the importance of considering genetic thrombophilias in unexplained arterial occlusions.
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