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Necrolytic migratory erythema.
Réka K Kovács1, Irma Korom, Attila Dobozy
1Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Hungary. kore@mail.szote.u-szegad.hu
Journal of Cutaneous Pathology
|February 10, 2006
Summary
Necrolytic migratory erythema, a skin condition, can be the sole indicator of a rare pancreatic tumor called glucagonoma. Early diagnosis through skin symptoms aids in detecting this rare glucagonoma syndrome.
Area of Science:
- Dermatology
- Oncology
- Endocrinology
Background:
- Necrolytic migratory erythema (NME) is a paraneoplastic dermatosis.
- Classical NME symptoms are linked to alpha-cell pancreatic islet cell tumors (glucagonomas).
- Extracutaneous signs typically include weight loss, diabetes, anemia, and diarrhea.
Observation:
- A 39-year-old woman presented with a 3-year history of recalcitrant psoriasiform eruption.
- No other extracutaneous symptoms were noted on routine examination.
- Abdominal CT revealed a pancreatic tail tumor, later confirmed as a glucagonoma.
Findings:
- Histologic examination suggested NME, confirmed as glucagonoma post-surgery.
- Skin symptoms resolved rapidly after pancreatic tumor resection.
- The patient remained symptom-free with no metastasis after 4 years.
Implications:
- This case highlights the infrequent presentation of glucagonoma syndrome with NME as the only symptom.
- Skin manifestations can be crucial diagnostic clues for glucagonoma syndrome.
- Prompt diagnosis and treatment of glucagonoma can lead to favorable outcomes.