Related Experiment Video

Updated: Aug 11, 2026

A Swine Model of Neonatal Asphyxia
10:36

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Long term outcome of birth asphyxiated infants

H A Begum1, A Rahman, S Anowar

  • 1Shaheed Suhrawardi Hospital, Dhaka.

Mymensingh Medical Journal : MMJ
|February 10, 2006
PubMed

Insights

Birth asphyxia in neonates can lead to significant long-term neurodevelopmental issues, with a high incidence of severe handicaps observed. Neonatal seizures are strongly associated with poor outcomes, highlighting the need for prevention.

Area of Science:

  • Pediatrics
  • Neonatology
  • Neurodevelopmental Pediatrics

Background:

  • Birth asphyxia is a critical condition in neonates.
  • Long-term neurodevelopmental sequelae are a concern for survivors of birth asphyxia.

Purpose of the Study:

  • To determine the incidence of long-term neurodevelopmental sequelae in neonates surviving birth asphyxia.
  • To identify potential risk factors associated with these sequelae.

Main Methods:

  • Prospective study of 58 neonates who survived birth asphyxia.
  • Follow-up evaluations at a Child Neurology Clinic up to 2 years of age.
  • Assessment of growth and development, with age correction for prematurity.

Main Results:

  • Only 51.7% of the study cohort completed the 2-year follow-up.
  • At 2 years, 40% had normal development, while 16.6% exhibited severe neurodevelopmental handicaps.
  • Neonatal seizures were present in 61% of handicapped children and were linked to poorer outcomes.

Conclusions:

  • Follow-up response was unsatisfactory, with a high rate of severe handicaps.
  • Post-asphyxia seizures are associated with adverse neurodevelopmental outcomes.
  • Prevention of perinatal asphyxia is crucial, and further long-term studies are warranted.

More Related Videos

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation09:03

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

Published on: August 15, 2018

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

Related Concept Videos

Atelectasis II: Pathophysiology01:10

Atelectasis II: Pathophysiology

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...