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Translocation (13;17)(q14;q25) as a novel chromosomal abnormality in acute myeloid leukemia-M4
Nihan Turhan1, Nüket Yürür-Kutlay, Pervin Topcuoglu
1Ankara University, Faculty of Medicine, Medical Genetics Department, Ankara, Turkey. tukun@medicine.ankara.edu
Leukemia Research
|February 14, 2006
Abstract:
We report a case of AML-M4 in which G-band karyotyping revealed a previously unreported t(13;17)(q14;q25) in metaphase preparations. The breakpoints at 13q14 and 17q25 are associated with poor prognosis. The MSF and FKHR genes are located on 17q25 and 13q14, respectively. This report of AML-M4 harboring t(13;17)(q14;q25) as a unique cytogenetic abnormality provides more data on the leukomogenesis with rearrangements related with 13q14 and 17q25.

