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Updated: Jul 13, 2026

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
Published on: June 21, 2016
Inflammation and sex steroid receptors: a motif for change
Jan J Brosens1, Eric W-F Lam, Malcolm G Parker
1Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London W12 ONN, United Kingdom.
Abstract:
Homeostasis in reproductive tissues requires integration of hormonal and inflammatory signals. In this issue of Cell, Zhu et al. (2006) discover that proinflammatory signals switch repressed steroid hormone receptors into transcriptional activators by targeting TAB2, an adaptor protein that tethers corepressors. These findings have implications for the treatment of endocrine-resistant cancers.
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