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Human responses to inhaled capsaicin are not inhibited by granisetron
N B Choudry1, J R McEwan, E A Lavender
1Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
British Journal of Clinical Pharmacology
|March 1, 1991
Abstract:
Cough is a common respiratory symptom, the mechanism of which is poorly understood. In this study the role of 5-HT3 receptors was investigated. Capsaicin-induced cough and increase in airways resistance were measured in six male volunteers before and after infusion with granisetron 160 micrograms kg-1 or placebo. Neither cough nor the increase in respiratory resistance was altered by the active treatment. These results suggest that 5-HT3 receptors are not involved in these two respiratory responses to inhaled capsaicin in humans.