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Solid phase peptide synthesis in water VI: evaluation of water-soluble coupling reagents for solid phase peptide

Keiko Hojo1, Mitsuko Maeda, Naoko Tanakamaru

  • 1Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan.

Protein and Peptide Letters
|February 14, 2006
PubMed

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...