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Updated: Aug 11, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
Published on: December 23, 2010
5-Lipoxygenase, leukotrienes biosynthesis and potential antileukotrienic agents
Josef Jampilek1, Martin Dolezal, Veronika Opletalova
1Zentiva a.s., U kabelovny 130, 102 37 Prague, Czech Republic. josef.jampilek@zentiva.cz
Abstract:
Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
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