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Updated: Aug 11, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Sneddon's syndrome: another migraine-stroke association?
G E Tietjen1, M M Al-Qasmi, P Gunda
1Department of Neurology, Medical University of Ohio, Toledo, OH 43614, USA. gtietjen@mco.edu
Cephalalgia : an International Journal of Headache
|February 14, 2006
Summary
Sneddon's syndrome links ischemic stroke and livedo reticularis. This review explores its association with headache, particularly migraine, suggesting livedo reticularis may be a stroke risk marker in migraineurs.
Area of Science:
- Neurology
- Vascular Neurology
- Dermatology
Background:
- Sneddon's syndrome is characterized by the co-occurrence of ischemic stroke and livedo reticularis.
- The relationship between Sneddon's syndrome, stroke, and headache, especially migraine, requires further investigation.
Purpose of the Study:
- To review the literature on Sneddon's syndrome, focusing on its association with headache and migraine.
- To evaluate the potential role of livedo reticularis as a stroke risk marker in migraine patients.
Main Methods:
- Systematic literature review of case reports and series on Sneddon's syndrome.
- Stratification of patients based on headache presence and characteristics.
- Analysis of demographic data, headache frequency, and anti-phospholipid antibody status.
Main Results:
- Among patients with Sneddon's syndrome, headache was reported in 58% of those with a headache reference, with migraine diagnosed in 27.5% of these.
- No significant difference in headache frequency was observed between patients with positive and negative anti-phospholipid antibodies.
- Histopathological, radiological, and serological data support a plausible association between Sneddon's syndrome and migraine.
Conclusions:
- A significant proportion of Sneddon's syndrome patients experience headache, often migraine.
- Livedo reticularis may serve as a potential risk marker for stroke in individuals with migraine, warranting further research.
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