Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormone-sensitive lipase knockouts.

Fredric B Kraemer1, Wen-Jun Shen

  • 1VA Palo Alto Health Care System, Palo Alto, CA, USA. fbk@stanford.edu

Nutrition & Metabolism
|February 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mechanisms underlying COVID-19 induced insulin resistance: a narrative review.

Frontiers in endocrinology·2026
Same author

Nherf2 is a major determinant of bile acid pool dynamics and contributes to regulation of Western diet-induced obesity.

American journal of physiology. Cell physiology·2025
Same author

Ablation of Steroidogenic Superoxide Dismutase 2 Increases Oxidative Stress and Diminishes Steroid Hormone Production.

Endocrinology·2025
Same author

HDL meets triglyceride.

Journal of lipid research·2025
Same author

Investigation of risk signatures associated with anoikis in thyroid cancer through integrated transcriptome and Mendelian randomization analysis.

Frontiers in endocrinology·2024
Same author

MicroRNA regulation of adrenal glucocorticoid and androgen biosynthesis.

Vitamins and hormones·2024
Same journal

Integrated serum and fecal metabolomics identifies compartment-specific metabolic remodeling in mice fed high-fat and Western diets.

Nutrition & metabolism·2026
Same journal

Prebiotic xylo-oligosaccharides cause modest taxonomic shifts in the gut microbiota but do not increase insulin sensitivity in insulin resistant individuals.

Nutrition & metabolism·2026
Same journal

Response of FTO gene polymorphisms to continuous caloric restriction diets on lipid and glycemic biomarkers in overweight and obese adults: a systematic review and meta-analysis.

Nutrition & metabolism·2026
Same journal

Vitamin E administration reduces liver enzyme levels in patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD): evidence from a systematic review and meta-analysis.

Nutrition & metabolism·2026
Same journal

Impact of L-carnitine supplementation on lipid profile parameters in overweight and obese women: a systematic review and meta-analysis of randomized controlled trials.

Nutrition & metabolism·2026
Same journal

Exosomal miRNA-714 derived from adipose tissue macrophages regulates adipocyte glucose and lipid metabolism via IGF1R targeting.

Nutrition & metabolism·2026
See all related articles

Hormone-sensitive lipase (HSL) is crucial for fat mobilization. HSL knockout mice resist obesity, showing altered adipose tissue and metabolism, highlighting HSL

Area of Science:

  • Biochemistry
  • Metabolic Research
  • Obesity Studies

Background:

  • Obesity treatments aim to reduce fat storage in adipocytes.
  • Hormone-sensitive lipase (HSL) is the primary enzyme for fatty acid (FFA) mobilization via lipolysis.
  • Understanding HSL's role is key to comprehending adipose tissue metabolism.

Purpose of the Study:

  • To investigate the functional significance of HSL in adipose metabolism.
  • To examine the effects of HSL deficiency on obesity and adipose tissue characteristics.
  • To elucidate HSL's role in lipolysis, lipogenesis, and adipocyte differentiation.

Main Methods:

  • Utilizing HSL knockout mouse models.
  • Analyzing adipose tissue composition (white vs. brown adipose tissue).

Related Experiment Videos

  • Assessing gene expression related to adipocyte differentiation and metabolism.

    • Main Results:

    • HSL knockout mice exhibit resistance to diet-induced and genetic obesity.
    • These mice show reduced white adipose tissue and increased brown adipose tissue.
    • Significant alterations in gene expression related to adipocyte differentiation and lipid metabolism were observed.

    Conclusions:

    • HSL is essential for complete hormone-stimulated lipolysis and plays a critical role in regulating adipose tissue mass.
    • Disruption of HSL function drastically reduces lipogenesis and alters overall adipose metabolism.
    • Targeting HSL may offer a novel therapeutic strategy for obesity management.