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Updated: Jun 12, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
HDL meets triglyceride
Tugce Akcan1, Fredric B Kraemer1
1Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, CA, USA.
Abstract:
The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyceride levels were associated with reduced HDL particle diameter and with increased HDL-TG. Using observational and Mendelian randomization analyses, HDL-TG levels were independently associated with atherosclerotic cardiovascular disease risk even after adjusting for multiple confounders and other risk factors. The results emphasize the need for a broader evaluation of lipid parameters that extends beyond traditional measurements and suggest that incorporating metrics like HDL-TG could enhance risk stratification.
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