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[Treatment of severe sarcoidosis using TNF-alpha-inhibitor (infliximab)]
Nils Milman1, Tina Brandt Sørensen
1H:S Rigshospitalet, Hjertecentret, Medicinsk Afdeling B, Afsnit for Lungetransplantation, og Arhus Universitetshospital, Arhus Sygehus, Lungemedicinsk Afdeling B. milman@rh.dk
Abstract:
Some patients with severe sarcoidosis are resistant to conventional treatment with corticosteroids and cytostatics. We describe a 29-year-old man with histologically verified sarcoidosis and persistent, pronounced enlargement of the peripheral lymph nodes, resistant to treatment with prednisolone and methotrexate. Following treatment with TNF-alpha-inhibitor (infliximab 3 mg/kg body weight), the lymph nodes regressed to normal size and the patient improved clinically. The patient had a total of four infliximab infusions, and the effect has persisted for more than two years.
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