Using three-dimensional acinar structures for molecular and cell biological assays
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Updated: Jul 30, 2026

08:33
Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells
Published on: April 25, 2014
Bin Xiang1, Senthil K Muthuswamy
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Methods in Enzymology
|February 14, 2006
Abstract:
Epithelial cells grown in three-dimensional matrix allows one to investigate biological processes in a setting that is closer to in vivo conditions than those obtained by growing cells on plastic culture dishes. Here we outline procedures that allow one to investigate molecular mechanisms that regulate formation and disruption of three-dimensional epithelial structures.

