Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subacute anthracycline cardiotoxicity.

Christopher L Hengel1, Prudence A Russell, Paul A Gould

  • 1Department of Cardiology, The Alfred Hospital, Melbourne, Australia.

Heart, Lung & Circulation
|February 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aortic Stenosis and Heart Failure With Preserved Ejection Fraction: A Cautionary Tale of Common Partners.

Circulation. Heart failure·2026
Same author

Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II.

JACC. Heart failure·2026
Same author

Using biofilm-targeting local antibiotics to treat recalcitrant medical device-associated infections: driveline infection as a model.

The Journal of antimicrobial chemotherapy·2026
Same author

Beta-blocker therapy after myocardial infarction: an umbrella review.

EClinicalMedicine·2026
Same author

CA in AF With LVSD With and Without LV Fibrosis: Results From the CAMERA-MRI II Trial.

JACC. Clinical electrophysiology·2026
Same author

Venous vascular pharmacology: how does it contribute to heart failure with preserved ejection fraction?

European heart journal. Cardiovascular pharmacotherapy·2026
Same journal

Initial 4-Year Experience with Microaxial Flow Pumps within a Tertiary Centre in Regional Australia.

Heart, lung & circulation·2026
Same journal

Health Care Workers' Preferences in the Delivery of Atrial Fibrillation Screening: A Systematic Review.

Heart, lung & circulation·2026
Same journal

Meta-Analysis of Randomised Controlled Trials on the Efficacy of Direct Oral Anticoagulants in Left Ventricular Thrombosis: An Updated Perspective.

Heart, lung & circulation·2026
Same journal

Letter to the Editor "Constructive Critique on CKM Implementation: Focusing on Non-Pharmacological Burden and Staging Utility" regarding: "Implementation Barriers to Evidence-Based Cardiovascular-Kidney-Metabolic Syndrome Management" by Davis et al. Heart Lung Circ. 2025;34:1060-1068.

Heart, lung & circulation·2026
Same journal

Reply to Letter to the Editor "Interpreting Biomarker Changes after Mechanical Thrombectomy in Intermediate-High Risk Pulmonary Embolism".

Heart, lung & circulation·2026
Same journal

Letter to the Editor "Interpreting Biomarker Changes After Mechanical Thrombectomy in Intermediate-High Risk Pulmonary Embolism" regarding: "Mechanical Thrombectomy Reduces Increased High Sensitivity Troponin Levels in Intermediate-High Risk Pulmonary Embolism" by Schell et al. Heart Lung Circ. 2025:35:259-270.

Heart, lung & circulation·2026
See all related articles

This study reports a rare case of subacute cardiotoxicity in a patient with acute myeloid leukemia treated with high-dose chemotherapy. The findings highlight isolated myocardial edema as a potential sign of anthracycline toxicity.

Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Acute myeloid leukemia (AML) treatment often involves intensive chemotherapy regimens.
  • Anthracyclines, such as idarubicin, are commonly used in AML consolidation therapy.
  • Cardiotoxicity is a known complication of anthracycline chemotherapy.

Observation:

  • A 25-year-old man with AML developed myopericarditis 17 days after high-dose cytarabine and idarubicin chemotherapy.
  • Echocardiography revealed transiently increased left ventricular wall thickness and diastolic dysfunction.
  • Endomyocardial biopsy demonstrated severe interstitial myocardial edema without cellular infiltrate or myofiber damage.

Findings:

  • This case presents the first description of subacute anthracycline cardiotoxicity with pathological evidence of isolated myocardial edema.

Related Experiment Videos

  • The observed myocardial edema suggests a non-inflammatory, non-necrotic mechanism of cardiac injury.

    • Implications:

    • This case expands the understanding of potential cardiotoxic effects of anthracyclines.
    • Early recognition of myocardial edema may aid in diagnosing and managing subacute chemotherapy-induced cardiotoxicity.
    • Further research is warranted to elucidate the mechanisms and clinical significance of isolated myocardial edema in chemotherapy recipients.