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Look-Align: an interactive web-based multiple sequence alignment viewer with polymorphism analysis support.

Payan Canaran1, Lincoln Stein, Doreen Ware

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Bioinformatics (Oxford, England)
|February 14, 2006
PubMed
Summary
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We created Look-Align, a web tool for viewing multiple sequence alignments. This versatile software, ideal for biological data visualization, can be integrated into various websites.

Area of Science:

  • Bioinformatics
  • Computational Biology

Background:

  • Multiple sequence alignments (MSAs) are crucial for understanding evolutionary relationships and protein function.
  • Existing visualization tools may lack interactivity or ease of integration.

Purpose of the Study:

  • To develop an interactive, web-based viewer for pre-computed multiple sequence alignments.
  • To create a generic, easily integrable tool for diverse bioinformatics applications.

Main Methods:

  • Developed Look-Align using Perl and open-source components.
  • Designed as an interactive, web-based application.

Main Results:

  • Look-Align provides an effective visualization solution for MSAs.
  • The tool is a generic, stand-alone application adaptable to different websites.

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Conclusions:

  • Look-Align offers a flexible and accessible method for visualizing biological sequence data.
  • The viewer enhances the utility of resources like the maize diversity website Panzea.