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Apollo 3: Multi-Species Genome Curation
Biorxiv : the Preprint Server for Biology
|June 22, 2026
Summary
Apollo 3 is a new genome annotation tool that integrates with JBrowse 2. This scalable software enables simultaneous multi-genome editing and synteny visualization for improved manual genome annotation.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- Manual genome annotation is critical for understanding gene function and genomic structure.
- Existing tools like Apollo, Artemis, and Otter have limitations in scalability and architecture.
- There is a need for updated tools that support collaborative and efficient genome annotation.
Purpose of the Study:
- To introduce Apollo 3, a novel manual genome annotation tool.
- To present its updated architecture and features for enhanced genome analysis.
- To demonstrate its utility as a standalone or collaborative platform.
Main Methods:
- Development of Apollo 3 with a modern, scalable architecture and technology stack.
- Integration with the JBrowse 2 genome browser for seamless visualization.
- Implementation of features for simultaneous multi-genome editing and synteny visualization.
Main Results:
- Apollo 3 offers a scalable and efficient solution for manual genome annotation.
- The tool supports simultaneous editing of multiple genomes.
- Synteny visualization is integrated to aid annotation accuracy.
Conclusions:
- Apollo 3 represents a significant advancement in manual genome annotation tools.
- Its design facilitates collaborative research and improves annotation workflows.
- The tool is suitable for both individual and large-scale genomic projects.
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