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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Coronary sinus is dilated and outwardly displaced in patients with mitral regurgitation: quantitative angiographic

Michael S Lee1, Atman P Shah, Ninh Dang

  • 1Cedars-Sinai Medical Center, and UCLA School of Medicine, Los Angeles, California, USA.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|February 14, 2006
PubMed

Insights

Patients with mitral regurgitation (MR) show a dilated coronary sinus (CS). The CS-great cardiac vein (GCV) perimeter correlates with MR severity, aiding device selection for percutaneous annuloplasty.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Anatomy

Background:

  • Percutaneous annuloplasty for mitral regurgitation (MR) is under clinical investigation.
  • Quantitative data on coronary sinus (CS) dimensions in MR is lacking.
  • Understanding CS anatomy is crucial for device development.

Purpose of the Study:

  • To define coronary sinus (CS) anatomy using venography.
  • To correlate CS dimensions with mitral regurgitation (MR) severity.
  • To inform the design of percutaneous annuloplasty devices.

Main Methods:

  • Coronary sinus (CS) venography in 57 patients (27 with MR, 30 without).
  • Echocardiography to assess MR severity and cardiac dimensions.
  • Quantitative analysis of CS ostial/proximal diameter and CS-great cardiac vein (GCV) perimeter.

Main Results:

  • Patients with MR exhibited significantly larger ostial CS diameter, proximal CS diameter, and CS-GCV perimeter compared to controls.
  • The CS-GCV perimeter showed a positive correlation with MR severity (P=0.02).
  • CS-GCV perimeter also correlated with pulmonary artery pressure (r=0.32, P<0.05).

Conclusions:

  • Mitral regurgitation (MR) is associated with coronary sinus (CS) dilation and outward displacement.
  • The CS-great cardiac vein (GCV) perimeter is a valuable metric, correlating with MR severity and pulmonary artery pressure.
  • These anatomical findings support the development of targeted percutaneous annuloplasty devices.
Abstract

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