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A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update
W Waelput1, P Brouckaert, D Broekaert
1Dept. of Pathology, Ghent University, De Pintelaan 185, 9000 Gent, Belgium. wim.waelput@ugent.be
Abstract:
Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptin's biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.
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