Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

FGF signalling in craniofacial development and developmental disorders.

X Nie1, K Luukko, P Kettunen

  • 1Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Bergen, Norway. xuguang.nie@gmail.com

Oral Diseases
|February 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinicopathological characteristics and molecular genetic features of malignant epithelioid neoplasm with EWSR1/FUS-CREB fusions in thorax of two cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same author

[Clinical analysis of 11 cases of oral adverse reactions associated with novel anti-tumor drugs].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same author

Nociceptor Neurons Facilitate Orthodontic Tooth Movement via Piezo2 in Mice.

Journal of dental research·2025
Same author

Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy in locally advanced rectal cancer (UNION): early outcomes of a multicenter randomized phase III trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Efficient Creation of Ultracold Ground State ^{6}Li^{40}K Polar Molecules.

Physical review letters·2024
Same author

[Clinicopathological analysis of cytological diagnosis of mesothelioma in serosal effusion].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2023
Same journal

Structural Validity and Factorial Analysis of the Brazilian Oral Health Impact Profile for Temporomandibular Disorders Instrument.

Oral diseases·2026
Same journal

Effects of Pistacia lentiscus Leaf-Twig and Resin (Mastic) Oils on Salivary Flow in Healthy Individuals.

Oral diseases·2026
Same journal

Oral Delivery of Bioencapsulated CTB-Pro-IGF-1 Enhances Bone Regeneration in a Pre-Clinical Rat Model of Jaw Osteoradionecrosis.

Oral diseases·2026
Same journal

Trends in Stage and Age at Diagnosis of Oral Squamous Cell Carcinoma Over Time: A Systematic Review and Meta-Analysis.

Oral diseases·2026
Same journal

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders.

Oral diseases·2026
Same journal

Authors' Reply "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
See all related articles

The Fibroblast Growth Factor (FGF) signaling pathway is vital for craniofacial development, regulating sutures, palates, and teeth. Disruptions in FGF signaling cause various developmental disorders, including craniosynostosis and cleft palate.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The Fibroblast Growth Factor (FGF) signaling pathway is evolutionarily conserved and essential for embryonic development.
  • FGF signaling is particularly critical in craniofacial development, influencing patterning, growth, and the formation of various structures.

Purpose of the Study:

  • To review the multifaceted roles of FGF signaling in craniofacial development.
  • To highlight recent advances in understanding FGF signaling's involvement in skeletogenesis, palatogenesis, gland formation, and tooth development.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on genetic mutations, signaling pathways, and developmental processes.

Main Results:

Related Experiment Videos

  • Mutations in FGF receptors are linked to craniosynostosis.
  • The Fgf10/Fgfr2b pathway is crucial for palate and salivary gland development; its perturbation can cause cleft palate.
  • FGF signaling regulates tooth development, with Fgfr2b essential for bud-stage development.
  • Fgfr4 is identified as a key mediator in myogenesis.

Conclusions:

  • FGF signaling is a central regulator of diverse craniofacial developmental processes.
  • Understanding FGF signaling pathways provides insights into developmental disorders and potential therapeutic targets.