Related Experiment Video
Updated: Aug 11, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Sweet's syndrome with bullous lesions]
Silvia Bielsa1, Manel Baradad, Rosa M Martí
1Servicio de Medicina Interna, Hospital Universitario Arnau de Vilanova, Alcalde Rivira Roure 80, 25198 Lleida, Spain. silviabmartn@yahoo.es
Actas Dermo-Sifiliograficas
|February 16, 2006
Summary
This case study details Sweet's syndrome presenting with unusual skin lesions like vesicles and bullae. While atypical lesions can signal malignancy, this patient showed no signs of cancer, though hematologic issues remain a consideration.
Area of Science:
- Dermatology
- Oncology
Background:
- Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, typically presents with tender, erythematous plaques and nodules.
- Atypical presentations, including vesicular and bullous lesions, are more common in patients with underlying conditions.
Observation:
- The case involves a patient with Sweet's syndrome exhibiting atypical skin manifestations: erythematous plaques, vesicles, and bullae.
- These atypical lesions were noted despite the absence of an underlying malignancy.
Findings:
- The patient's Sweet's syndrome presented with a combination of typical plaques and atypical vesicular/bullous lesions.
- No association with malignancy was found in this specific case.
Implications:
- Atypical skin lesions in Sweet's syndrome warrant careful evaluation, as they can be associated with malignancy, particularly hematologic malignancies.
- Even in the absence of malignancy, the differential diagnosis for such presentations should include systemic conditions.
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