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Updated: Aug 11, 2026

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
Published on: June 22, 2017
Oscillatory pallidal local field potential activity correlates with involuntary EMG in dystonia
C C Chen1, A A Kühn, K-T Hoffmann
1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK.
Abstract:
The pathophysiology of dystonia is unclear. The authors recorded local field potentials (LFPs) from deep brain stimulation electrodes implanted in the pallidum of 13 dystonic patients. LFP power correlated with the level of dystonic EMG in the sternocleidomastoid, with maximal positive correlations at the lower contacts of pallidal electrodes. The data suggest that the neuronal synchronization indexed by LFP oscillations in the globus pallidus may be mechanistically linked to dystonic EMG activity.
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