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Updated: Aug 11, 2026
08:03
Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
Published on: June 25, 2017
Glucose, insulin and myocardial ischaemia
Philippe Devos1, René Chioléro, Greet Van den Berghe
1Department of Intensive Care, Sart Tilman University Hospital, Liège, Belgium.
Current Opinion in Clinical Nutrition and Metabolic Care
|February 16, 2006
Summary
Hyperglycaemia is toxic during myocardial ischaemia, but insulin therapy offers benefits. Recent evidence suggests glucose-insulin-potassium solutions may improve survival, though further research is needed.
Area of Science:
- Cardiology
- Metabolic Medicine
- Biochemistry
Background:
- Glucose metabolism and insulin therapy are critical during myocardial ischaemia.
- Hyperglycaemia presents toxic cellular effects, exacerbating myocardial ischaemia.
- Insulin plays a crucial role in managing glucose levels and offers protective effects.
Purpose of the Study:
- To review the physiological and physiopathological consequences of hyperglycaemia in myocardial ischaemia.
- To examine the multifaceted effects of insulin on vascular tone, inflammation, energy metabolism, and apoptosis.
- To analyze clinical data on intensive insulin therapy and glucose-insulin-potassium solutions in myocardial ischaemia and heart failure.
Main Methods:
- Literature review of physiological, physiopathological, and clinical data.
- Analysis of hyperglycaemia's impact on myocardial ischaemia mechanisms.
- Evaluation of insulin's effects on cellular pathways and clinical outcomes.
Main Results:
- Hyperglycaemia increases inducible nitric oxide synthase activity and inflammation.
- Insulin demonstrates anti-inflammatory and anti-apoptotic properties.
- Glucose-insulin-potassium solutions show potential for improving survival post-myocardial infarction or surgery, pending confirmation.
Conclusions:
- Hyperglycaemia is detrimental, while insulin is beneficial in acute myocardial ischaemia.
- Current evidence supports insulin's benefits, alone or in glucose-insulin-potassium therapy, for tight glucose control.
- Further research is required to validate these findings and establish optimal glucose control thresholds.
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