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Mixed lateral preference in posttraumatic stress disorder.

Kasey M Saltzman1, Carl F Weems, Allan L Reiss

  • 1Stanford University School of Medicine, Stanford, CA 94305, USA.

The Journal of Nervous and Mental Disease
|February 16, 2006
PubMed
Summary
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Children with post-traumatic stress disorder (PTSD) show increased mixed laterality. This suggests a link between neurological differences and PTSD symptom severity in traumatized youth.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Child Psychiatry

Background:

  • Adults with post-traumatic stress disorder (PTSD) exhibit higher rates of mixed laterality.
  • Mixed laterality refers to inconsistent dominance of one side of the body for functions like handedness.
  • The relationship between mixed laterality and PTSD in children remains under-investigated.

Purpose of the Study:

  • To investigate if mixed laterality is more prevalent in children with a history of interpersonal trauma.
  • To determine if PTSD symptom severity correlates with mixed laterality in traumatized children.
  • To explore potential neurological underpinnings of PTSD symptom expression in early life.

Main Methods:

  • Evaluation of 59 children with a history of interpersonal trauma using the Clinician Administered PTSD Scale for Children and Adolescents.

Related Experiment Videos

  • Assessment of handedness using the Edinburgh Handedness Inventory in traumatized children and 40 matched healthy controls.
  • Statistical analysis comparing mixed laterality rates between PTSD diagnostic groups and controls, and correlating symptom severity with laterality.

    • Main Results:

    • Traumatized children exhibiting PTSD symptoms demonstrated significantly increased mixed laterality compared to healthy controls.
    • Children meeting DSM-IV criteria for PTSD showed higher rates of mixed laterality than those with subthreshold symptoms.
    • A positive correlation was observed between PTSD symptom severity and the degree of mixed laterality within the traumatized group.

    Conclusions:

    • Mixed laterality is associated with PTSD in traumatized children, mirroring findings in adults.
    • Increased mixed laterality may indicate neurological abnormalities that correlate with the severity of PTSD symptoms.
    • These findings suggest a potential neurodevelopmental component influencing PTSD expression in children exposed to trauma.