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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA
David T Puerta1, Mauro Botta, Christoph J Jocher
1Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA 92093, USA.
Abstract:
Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.
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