Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fatal flaws in the case for prepatterning in the mouse egg.

Takashi Hiiragi1, Davor Solter

  • 1Department of Developmental Biology, Max-Planck Institute of Immunobiology, Freiburg, Germany. hiiragi@immunbio.mpg.de

Reproductive Biomedicine Online
|February 16, 2006
PubMed
Summary

The mouse preimplantation embryo's development, specifically predetermination and polarity, remains debated. Comparing mammalian development to non-mammalian models requires careful data analysis and unbiased interpretation of research findings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Boundary geometry controls a topological defect transition that determines lumen nucleation in embryonic development.

Nature materials·2026
Same author

Boundary-guided cell alignment drives mouse epiblast maturation.

Nature physics·2026
Same author

Optimality as a framework for understanding developmental robustness.

Trends in cell biology·2025
Same author

Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness.

Nature cell biology·2025
Same author

Temporal variability and cell mechanics control robustness in mammalian embryogenesis.

Science (New York, N.Y.)·2024
Same author

Competence for neural crest induction is controlled by hydrostatic pressure through Yap.

Nature cell biology·2024

Area of Science:

  • Developmental Biology
  • Embryology
  • Genetics

Background:

  • The study addresses the ongoing controversy regarding predetermination and polarity in mouse preimplantation embryos.
  • It questions the comparability of early mammalian development mechanisms to those in non-mammalian model organisms.

Discussion:

  • Critiques a recent article by Gardner, highlighting the need for careful, unbiased reading of scientific reports.
  • Emphasizes the importance of providing robust data to support claims in developmental biology research.

Key Insights:

  • The presence or absence of predetermination and polarity in early mammalian embryos is not definitively established.
  • Discrepancies in understanding may arise from differing interpretations of developmental mechanisms across species.

Related Experiment Videos

Outlook:

  • Further research is needed to clarify the mechanisms of early mammalian development.
  • Resolving controversies requires rigorous data presentation and objective scientific discourse.