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Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on

Peter Ugocsai1, Stefan Barlage, Ashraf Dada

  • 1Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg 93053, Germany.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|February 16, 2006
PubMed

Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased availability of HbHp complexes triggers the upregulation of surface CD163, and also results in a dose-dependent secretion of IL-6 and IL-10.

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