Cytokine responses in dogs infected with Ehrlichia canis Oklahoma strain

Ehrlichia canis causes persistent infection of monocytes/macrophages and causes canine monocytic ehrlichiosis. Other than antibody development, very little is known how the dog immune system responds to this pathogen. In the present study, we examined the temporal expression of cytokine mRNA in peripheral blood mononuclear cells (PBMCs) from dogs inoculated with E. canis Oklahoma strain. We also examined production of interferon-gamma (IFN-gamma) by canine PBMCs infected with E. canis in vitro.