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Related Experiment Videos

Hearing genes and cisplatin deafness: a pilot study.

Christine Knoll1, Richard J H Smith, Carol Shores

  • 1Division of Pediatric Hematology-Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7220, USA.

The Laryngoscope
|February 17, 2006
PubMed
Summary

Genetic screening did not reveal a significant link between common hearing gene mutations and cisplatin-induced ototoxicity in pediatric cancer patients. Further research into other genes is needed to predict hearing loss risk.

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Area of Science:

  • Pediatric Oncology
  • Genetics
  • Ototoxicity Research

Background:

  • Cisplatin is a vital chemotherapy for pediatric solid tumors.
  • Sensorineural hearing loss is a significant dose-limiting toxicity of cisplatin.
  • Individual susceptibility influences cisplatin-induced ototoxicity.

Purpose of the Study:

  • To investigate the hypothesis that mutations or polymorphisms in hearing genes are more prevalent in pediatric patients experiencing cisplatin ototoxicity.
  • To identify potential genetic predictors of cisplatin-induced hearing loss.

Main Methods:

  • Retrospective mutation screening of GJB2 and SLC26A4 genes.
  • Screening for three mitochondrial DNA (mtDNA) mutations.
  • Analysis of DNA from 11 pediatric patients with severe hearing loss after cisplatin treatment.

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Main Results:

  • Only one patient (9.1%) was a carrier for the 35delG mutation.
  • This prevalence was not statistically significant compared to the general population (2.5%).
  • No significant association was found between the screened genes and cisplatin ototoxicity.

Conclusions:

  • The examined hearing genes (GJB2, SLC26A4, and three mtDNA mutations) are unlikely contributors to cisplatin ototoxicity.
  • Further investigation into other hearing-related genes is warranted to identify predictors of cisplatin-induced hearing loss.