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Neonatal sepsis 1991-2001: prevalent bacterial agents and antimicrobial susceptibilities in Bahrain

Khalid M Bindayna1, Afaf Jamsheer, Eman Farid

  • 1Department of Microbiology, Immunology and Infectious Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain. bindayna@agu.edu.bh

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|February 18, 2006
PubMed

Insights

Neonatal sepsis is primarily caused by Gram-positive bacteria like coagulase-negative Staphylococcus. While antibiotic sensitivity remains largely stable, rising fungal infections require attention for effective neonatal care.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Neonatal sepsis remains a significant cause of mortality and morbidity worldwide.
  • Understanding causative organisms and their antimicrobial susceptibility is crucial for effective treatment and prevention strategies.

Purpose of the Study:

  • To track changes in neonatal sepsis pathogens and antibiotic sensitivities over an 11-year period.
  • To evaluate the effectiveness of group B streptococci (GBS) screening policies in local settings.

Main Methods:

  • Retrospective review of medical records for infants with positive blood cultures.
  • Data collected from two hospitals between 1991-2001 and 1999-2001.

Main Results:

  • Culture-proven bacteremia occurred in 4.19% of neonates.
  • Coagulase-negative Staphylococcus (CoNS) was the most common pathogen (41%), followed by Escherichia coli (10%).
  • An increasing trend in Candida isolation (5.7%) was observed, alongside stable sensitivities to penicillin G, erythromycin, and clindamycin for Gram-positive bacteria.

Conclusions:

  • High-quality specimens are vital for accurate identification of pathogens like CoNS.
  • The rising incidence of fungal infections necessitates targeted interventions.
  • Local epidemiological data should guide the development of specific policies for GBS prevention.
Abstract

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