First passage times and asymmetry of DNA translocation
Rhonald C Lua1, Alexander Y Grosberg
1Department of Physics, University of Minnesota, 116 Church Street SE, Minneapolis, Minnesota 55455, USA.
Abstract:
Motivated by experiments in which single-stranded DNA with a short hairpin loop at one end undergoes unforced diffusion through a narrow pore, we study the first passage times for a particle, executing one-dimensional Brownian motion in an asymmetric sawtooth potential, to exit one of the boundaries. We consider the first passage times for the case of classical diffusion, characterized by a mean-square displacement of the form <(Delta(x))2> approximately t, and for the case of anomalous diffusion or subdiffusion, characterized by a mean-square displacement of the form <(Delta(x))2> approximately t(gamma) with 0
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