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Related Experiment Videos

Beta-receptor sensitivity in autonomic failure.

S M Baser1, R T Brown, M T Curras

  • 1Clinical Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Neurology
|July 1, 1991
PubMed
Summary
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Patients with autonomic failure show impaired baroreflex modulation and lack plasma norepinephrine and renin responses to isoproterenol, unlike normal subjects. This suggests autonomic dysfunction affects cardiovascular and renal regulation.

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Function
  • Pharmacology

Background:

  • Autonomic failure impairs the body's ability to regulate blood pressure and heart rate.
  • Beta-adrenergic receptor function is crucial for cardiovascular responses.
  • Understanding these responses is vital for managing autonomic disorders.

Purpose of the Study:

  • To investigate cardiovascular, plasma norepinephrine (NE), and plasma renin activity (PRA) responses to isoproterenol infusion in patients with autonomic failure versus normal subjects.
  • To assess baroreflex modulation and beta-adrenergic receptor sensitivity in autonomic dysfunction.
  • To elucidate the role of reflexive cardiovascular and renal mechanisms in NE and PRA responses.

Main Methods:

  • Isoproterenol infusion was administered to patients with multiple system atrophy, pure autonomic failure (PAF), and healthy controls.

Related Experiment Videos

  • Cardiovascular parameters (blood pressure) and plasma levels of NE and PRA were measured.
  • Dose-response relationships for blood pressure were analyzed.

    • Main Results:

    • Patients with autonomic failure (MSA and PAF) exhibited impaired baroreflex modulation, indicated by more negative blood pressure response/dose slopes.
    • Pure autonomic failure (PAF) patients showed a leftward shift, suggesting beta-adrenergic receptor supersensitivity.
    • Normal subjects displayed proportional increases in plasma NE and PRA with isoproterenol levels, which was absent in autonomic failure patients despite blood pressure reduction.

    Conclusions:

    • Autonomic failure is associated with impaired baroreflex control of blood pressure.
    • Beta-adrenergic receptor supersensitivity may occur in pure autonomic failure.
    • Reflexive cardiovascular and renal mechanisms are essential for mediating plasma NE and PRA responses to isoproterenol in healthy individuals, but this response is blunted in autonomic failure.